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丹麦普通医疗中成年频繁就诊者的药物处方:一项基于人群的研究。

Drug prescription for adult frequent attenders in Danish general practice: a population-based study.

作者信息

Vedsted Peter, Sørensen Henrik Toft, Mortensen Jens Tølbøll

机构信息

The Research Unit and Department of General Practice, University of Aarhus, Denmark.

出版信息

Pharmacoepidemiol Drug Saf. 2004 Oct;13(10):717-24. doi: 10.1002/pds.939.

Abstract

PURPOSE

To analyse the association between daytime frequent attendance in general practice and drug use, i.e. type of drug used and prevalence of polypharmacy.

METHODS

A population-based cross-sectional study of individual face-to-face contacts with 179 Danish general practices (320 general practitioners, GPs) in the county of Northern Jutland, Denmark and the drug use of the 371 897 inhabitants aged 20 and over. Data on contacts and reimbursed drugs were obtained during the year of 1997 from the Health Insurance Registry. Frequent attenders (FAs) were defined as the 10% most FAs in 12 months. We measured the prevalence difference (PD) and the prevalence ratio (PR) of drug use and polypharmacy (drugs from five or more ATC groups) among FAs.

RESULTS

FAs received prescriptions in 95% of the cases and utilised 27% of all prescribed drugs. Compared with the 50% least attending patients, the highest absolute prevalence of drug use among FAs was found for antibiotics (PD: 22.6-34.5), strong analgesics and psychotropics (PD: 16.0-38.5) and cardiovascular (PD: 4.2-46.2), musculoskeletal (PD: 16.3-29) and gastrointestinal drugs (PD: 10.8-39.9). The FAs had an increased PR for receiving a drug (1.1-1.6) and their polypharmacy PD was high (4.0-46.3). The association between frequent attendance and the prevalence of polypharmacy was strong (PR = 6.7-36.7).

CONCLUSIONS

Frequent attendance in general practice is strongly associated with drug use and polypharmacy. FAs account for a high proportion of the prescription workload, and some disease groups are very common among FAs.

摘要

目的

分析全科医疗中白天频繁就诊与药物使用之间的关联,即所用药物类型和多重用药的患病率。

方法

在丹麦日德兰半岛北部郡对179家丹麦全科诊所(320名全科医生)进行基于人群的面对面接触横断面研究,并研究371897名20岁及以上居民的药物使用情况。1997年从健康保险登记处获取接触和报销药物的数据。频繁就诊者(FAs)定义为12个月内就诊最频繁的10%人群。我们测量了频繁就诊者中药物使用和多重用药(来自五个或更多解剖治疗学化学分类组的药物)的患病率差异(PD)和患病率比(PR)。

结果

频繁就诊者在95%的病例中接受了处方,使用了所有处方药物的27%。与就诊最少的50%患者相比,频繁就诊者中抗生素(PD:22.6 - 34.5)、强效镇痛药和精神药物(PD:16.0 - 38.5)以及心血管药物(PD:4.2 - 46.2)、肌肉骨骼药物(PD:16.3 - 29)和胃肠道药物(PD:10.8 - 39.9)的药物使用绝对患病率最高。频繁就诊者接受药物治疗的PR升高(1.1 - 1.6),且他们的多重用药PD较高(4.0 - 46.3)。频繁就诊与多重用药患病率之间的关联很强(PR = 6.7 - 36.7)。

结论

全科医疗中的频繁就诊与药物使用和多重用药密切相关。频繁就诊者占处方工作量的很大比例,并且某些疾病组在频繁就诊者中非常常见。

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