Delineating noncovalent interactions between the azinomycins and double-stranded DNA: importance of the naphthalene substitution pattern on interstrand cross-linking efficiency.

作者信息

Landreau Cyrille A S, LePla Rachel C, Shipman Michael, Slawin Alexandra M Z, Hartley John A

机构信息

Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K., School of Chemistry, University of St. Andrews, Purdie Building, St. Andrews, Fife KY16 9ST, UK.

出版信息

Org Lett. 2004 Sep 30;6(20):3505-7. doi: 10.1021/ol048653y.

DOI:10.1021/ol048653y

PMID:15387534

Abstract

[reaction: see text] Using a series of synthetic azinomycin analogues, it is shown that the efficiency of in vitro DNA interstrand cross-linking is markedly reduced when either the C-5' methyl group or both the C-5' methyl and C-3' methoxy groups are deleted from the naphthalene ring.

摘要