二氟苯基硫烷基甲基自由基和二氟亚甲基双自由基合成子：偕二氟亚甲基结构单元。
Difluorophenylsulfanylmethyl radical and difluoromethylene diradical synthons: gem-difluoromethylene building block.
作者信息
Reutrakul Vichai, Thongpaisanwong Thanchanok, Tuchinda Patoomratana, Kuhakarn Chutima, Pohmakotr Manat
机构信息
Department of Chemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
出版信息
J Org Chem. 2004 Oct 1;69(20):6913-5. doi: 10.1021/jo0489768.
Bromodifluorophenylsulfanylmethane has been demonstrated to be a highly versatile gem-difluoromethylene (CF2) building block via the reaction of difluorophenylsulfanylmethyl radical with olefins. gem-Difluoroalkenes and products containing a midchain CF2 group and with manipulatable functionality can be readily synthesized. The first example of a gem-difluoromethylene radical synthon is also reported.
通过二氟苯基硫烷基甲基自由基与烯烃的反应，已证明溴二氟苯基硫烷基甲烷是一种高度通用的偕二氟亚甲基（CF2）结构单元。偕二氟烯烃以及含有中链CF2基团且具有可操控官能团的产物能够很容易地合成出来。还报道了偕二氟亚甲基自由基合成子的首个实例。
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