瘢痕性类天疱疮：发病机制、诊断与治疗

Ocular cicatricial pemphigoid: pathogenesis, diagnosis and treatment.

作者信息

Ahmed Muna, Zein Ghassan, Khawaja Faizullah, Foster C Stephen

机构信息

Ocular Immunology and Uveitis Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114-3069, USA.

出版信息

Prog Retin Eye Res. 2004 Nov;23(6):579-92. doi: 10.1016/j.preteyeres.2004.05.005.

DOI:10.1016/j.preteyeres.2004.05.005

PMID:15388075

Abstract

Understanding of ocular cicatricial pemphigoid (OCP) has changed dramatically over the last three decades. Progress in basic science research in mucous membrane pemphigoid has been instrumental in outlining the key immune processes that participate in the autoimmune response. Immunomodulatory therapy has provided an avenue for preserving vision and preventing potentially fatal consequences of systemic pemphigoid. In this chapter we focus attention on the immunologic basis for disease and treatment strategies. We propose an algorithmic approach to diagnosis and management of OCP.

摘要

在过去三十年里，人们对瘢痕性类天疱疮（OCP）的认识发生了巨大变化。黏膜类天疱疮基础科学研究的进展有助于勾勒出参与自身免疫反应的关键免疫过程。免疫调节疗法为保护视力和预防系统性类天疱疮的潜在致命后果提供了一条途径。在本章中，我们将重点关注该疾病的免疫学基础和治疗策略。我们提出了一种针对OCP诊断和管理的算法方法。