Whitney JoAnne D, Parkman Sharon
University of Washington School of Nursing, Seattle 98195, USA.
Biol Res Nurs. 2004 Oct;6(2):79-89. doi: 10.1177/1099800404268939.
Supplemented postoperative activity was compared to standard activity for effects on wound healing, subcutaneous tissue perfusion, and oxygen (PscO2) following hip replacement (THR).
58 patients were randomized to standard post-THR activity (N = 27) or supplemental activity (N = 31) (arm and leg exercises, walking protocol). PscO2was measured with a microelectrode/tonometer system and perfusion determined by oxygen response. Healing was evaluated by (1) tissue cellularity, (2) mRNA for pro collagen, (3) hydroxyproline, and (4) DNA content obtained from a subcutaneous implant removed on the 7th postoperative day.
Activity significantly increased DNA levels, but did not increase PscO2, perfusion, cellularity, or collagen measures.
Healing measures were not improved with increased activity levels. However, activity did not reduce PscO2or wound healing. The majority of patients adhered to additional activity and tolerated the protocol well. Increased activity was associated with earlier discharge, suggesting other recovery-related benefits.
比较髋关节置换术（THR）后补充活动与标准活动对伤口愈合、皮下组织灌注和氧分压（PscO2）的影响。
58例患者被随机分为标准THR术后活动组（N = 27）或补充活动组（N = 31）（手臂和腿部运动、步行方案）。用微电极/眼压计系统测量PscO2，并通过氧反应测定灌注。通过以下指标评估愈合情况：（1）组织细胞密度，（2）前胶原mRNA，（3）羟脯氨酸，以及（4）术后第7天取出的皮下植入物的DNA含量。
活动显著增加了DNA水平，但未增加PscO2、灌注、细胞密度或胶原指标。
增加活动水平并未改善愈合指标。然而，活动并未降低PscO2或伤口愈合情况。大多数患者坚持额外活动且对方案耐受性良好。增加活动与更早出院相关，提示存在其他与恢复相关的益处。
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