吸入海洛因热解产物后出现的可逆性帕金森综合征与四氢生物蝶呤缺乏有关。

Reversible parkinsonism following heroin pyrolysate inhalation is associated with tetrahydrobiopterin deficiency.

作者信息

Heales Simon, Crawley Francesca, Rudge Peter

机构信息

Neurometabolic Unit, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.

出版信息

Mov Disord. 2004 Oct;19(10):1248-51. doi: 10.1002/mds.20158.

DOI:10.1002/mds.20158

PMID:15390004

Abstract

A patient who inhaled heroin vapour (chasing the dragon), resulting in temporary parkinsonism, is described. A reversible deficiency of tetrahydrobiopterin, causing altered dopamine metabolism, is demonstrated as the metabolic basis of this aspect of the encephalopathy.

摘要

描述了一名吸入海洛因蒸汽（追龙）导致暂时性帕金森症的患者。四氢生物蝶呤的可逆性缺乏导致多巴胺代谢改变，被证明是该脑病这一方面的代谢基础。