卡巴拉汀对亨廷顿舞蹈病运动和认知障碍的影响。

Effects of rivastigmine on motor and cognitive impairment in Huntington's disease.

作者信息

de Tommaso Marina, Specchio Nicola, Sciruicchio Vittorio, Difruscolo Olimpia, Specchio Luigi Maria

机构信息

Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy.

出版信息

Mov Disord. 2004 Dec;19(12):1516-8. doi: 10.1002/mds.20235.

DOI:10.1002/mds.20235

PMID:15390067

Abstract

To evaluate the efficacy of rivastigmine on motor and cognitive impairment in Huntington's disease (HD), we carried out a prospective, open-label, randomized, controlled study. Twenty-one HD patients were enrolled: 14 were randomly sorted into medication and 7 to no-treatment groups. Clinical and demographic features were similar between groups. After 8 months, an efficacy evaluation was carried out to compare the two groups. The improvement of cholinergic transmission in HD patients seemed to have a slight effect in ameliorating cognitive performance and slowing motor deterioration.

摘要

为评估卡巴拉汀对亨廷顿舞蹈病（HD）运动和认知障碍的疗效，我们开展了一项前瞻性、开放标签、随机对照研究。招募了21名HD患者：14名被随机分为用药组，7名分为未治疗组。两组的临床和人口统计学特征相似。8个月后，进行疗效评估以比较两组。HD患者胆碱能传递的改善似乎在改善认知表现和减缓运动恶化方面有轻微作用。