游离脂肪酸对单层培养的胎鼠神经元生长激素释放激素分泌的刺激作用。

Stimulatory effect of free fatty acids on growth hormone releasing hormone secretion by fetal rat neurons in monolayer culture.

作者信息

Señaris R M, Lewis M D, Lago F, Dominguez F, Scanlon M F, Dieguez C

机构信息

Department of Physiology, Faculty of Medicine, University of Santiago, Spain.

出版信息

Neurosci Lett. 1992 Jan 20;135(1):80-2. doi: 10.1016/0304-3940(92)90140-3.

DOI:10.1016/0304-3940(92)90140-3

PMID:1542440

Abstract

The effects of free fatty acids (FFAs) on growth hormone releasing hormone (GHRH) secretion by fetal rat cortical and hypothalamic neurons in monolayer culture have been investigated. Treatment with caprylic or oleic acids for 90 min, induced a dose-dependent increase in GHRH secretion. The stimulatory effect of caprylic acid was time-dependent, being present after 90 min and 5 h but not after 24 h. Finally, GHRH release induced by 56 mM KCl or by the calcium ionophore A23187 was not modified by 5 x 10(-3) M caprylic acid. These data support a role for FFAs on GHRH secretion.

摘要

研究了游离脂肪酸（FFA）对单层培养的胎鼠皮质和下丘脑神经元生长激素释放激素（GHRH）分泌的影响。用辛酸或油酸处理90分钟，可诱导GHRH分泌呈剂量依赖性增加。辛酸的刺激作用具有时间依赖性，在90分钟和5小时后出现，但在24小时后未出现。最后，56 mM氯化钾或钙离子载体A23187诱导的GHRH释放不受5×10^(-3) M辛酸的影响。这些数据支持FFA在GHRH分泌中起作用。