作为照射后增敏剂的生物还原药物：双功能制剂与SR 4233及丝裂霉素C类似物EO9的比较

Bioreductive drugs as post-irradiation sensitizers: comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9.

作者信息

Adams G E, Stratford I J, Edwards H S, Bremner J C, Cole S

机构信息

Medical Research Council Radiobiology Unit, Didcot, Oxfordshire, U.K.

出版信息

Int J Radiat Oncol Biol Phys. 1992;22(4):717-20. doi: 10.1016/0360-3016(92)90510-o.

DOI:10.1016/0360-3016(92)90510-o

PMID:1544844

Abstract

Various bioreductive drugs that are potent hypoxic cell cytotoxins can also function as effective potentiators of radiation action when administered in vivo post irradiation. There is evidence that a contributory mechanism to this potentiation is enhanced sensitivity to the bioreductive drugs exhibited by cells that are damaged sublethally by radiation.

摘要

多种作为强效乏氧细胞细胞毒素的生物还原药物，在照射后体内给药时，也可作为辐射作用的有效增效剂。有证据表明，这种增效作用的一个促成机制是，受到辐射亚致死损伤的细胞对生物还原药物表现出更高的敏感性。