血管内淋巴瘤——溶血性贫血和神经系统疾病的罕见病因。

Intravascular lymphoma - a rare cause of hemolytic anemia and neurologic disorders.

作者信息

Weisel Katja C, Brugger Wolfram, Kröber Stefan M, Kaiserling Edwin, Kanz Lothar

机构信息

Department of Hematology, Oncology and Immunology, University of Tübingen, Medical Center, Otfried-Müller-Strasse 10, D-72076 Tübingen, Germany.

出版信息

Hematol J. 2004;5(5):444-6. doi: 10.1038/sj.thj.6200378.

DOI:10.1038/sj.thj.6200378

PMID:15448672

Abstract

Intravascular lymphoma is an uncommon and often overlooked form of non-Hodgkin's lymphoma characterized by extensive proliferation of lymphoid cells within the lumina of small and medium-sized vessels. Clinical symptoms of the disease are variable and often nonspecific, mostly neurologic in nature. With an aggressive course, intravascular lymphomatosis has a poor prognosis and is rarely diagnosed ante mortem. We describe here a 76-year-old woman with the clinical diagnoses of hemolytic anemia and progressive lethargy where intravascular lymphomatosis turned out as the underlying cause of the disease.

摘要

血管内淋巴瘤是一种罕见且常被忽视的非霍奇金淋巴瘤，其特征是中小血管腔内的淋巴细胞广泛增殖。该疾病的临床症状多样且往往不具特异性，主要为神经系统症状。血管内淋巴瘤病情进展迅速，预后较差，生前很少被诊断出来。我们在此描述一名76岁女性，临床诊断为溶血性贫血和进行性嗜睡，最终发现血管内淋巴瘤是该疾病的根本原因。