Kaufmann Horacio, Nahm Kirsty, Purohit Dushyant, Wolfe David
Department of Neurology, Mount Sinai School of Medicine, Box 1052, New York, NY 10029, USA.
Neurology. 2004 Sep 28;63(6):1093-5. doi: 10.1212/01.wnl.0000138500.73671.dc.
The authors report the clinical and postmortem neuropathologic findings of two patients, one with Parkinson disease (PD) and one with dementia with Lewy bodies (DLB), both of whom initially sought treatment for isolated autonomic failure. These cases suggest that neurodegeneration in PD and DLB may begin outside the CNS in autonomic postganglionic neurons, a finding with potential diagnostic and therapeutic implications.
作者报告了两名患者的临床及尸检神经病理学发现，一名患有帕金森病（PD），另一名患有路易体痴呆（DLB），两人最初均因单纯自主神经功能衰竭而寻求治疗。这些病例表明，PD和DLB中的神经变性可能始于中枢神经系统外的自主神经节后神经元，这一发现具有潜在的诊断和治疗意义。
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