Cahali Michel B, Formigoni Gilberto G S, Gebrim Eloisa M M S, Miziara Ivan D
Division of Otolaryngology, Hospital das Clínicas, University of Sao Paulo Medical School, Brazil.
Sleep. 2004 Aug 1;27(5):942-50. doi: 10.1093/sleep/27.5.942.
To compare the lateral pharyngoplasty procedure with uvulopalatopharyngoplasty (UPPP) in the treatment of obstructive sleep apnea hypopnea syndrome (OSAHS).
Prospective randomized study.
Academic tertiary center.
Twenty-seven adults with OSAHS originally selected for treatment with UPPP.
Patients were randomly assigned to 2 groups: in one group, we performed the lateral pharyngoplasty (15 cases), and in the other, we did the UPPP (12 cases).
We compared treatment outcomes through the evaluation of OSAHS-related symptoms and the analysis of polysomnographic tests and computed tomography measurements of pharyngeal airway. The lateral pharyngoplasty group achieved a statistically greater reduction in body weight, excessive daytime sleepiness, and apnea-hypopnea index. In addition, only in this group did we observe a statistically significant increase in the amount of deep sleep stages and improvement in morning headaches. Patients from the UPPP group did not present significant changes in the polysomnographic parameters. Pharyngeal airway measurement outcomes were similar in both groups and did not reflect the clinical and polysomnographic differences we observed.
Lateral pharyngoplasty produces better clinical and polysomnographic outcomes in the treatment of OSAHS than does UPPP, without resultant differences in the cross-sectional measurements of the pharyngeal airway between these treatments.
比较咽侧壁成形术与悬雍垂腭咽成形术(UPPP)治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的效果。
前瞻性随机研究。
学术性三级中心。
最初选择接受UPPP治疗的27例成年OSAHS患者。
患者被随机分为两组:一组接受咽侧壁成形术(15例),另一组接受UPPP(12例)。
我们通过评估与OSAHS相关的症状以及分析多导睡眠图测试和咽部气道的计算机断层扫描测量结果来比较治疗效果。咽侧壁成形术组在体重减轻、日间过度嗜睡和呼吸暂停低通气指数方面的降低具有统计学意义。此外,仅在该组中我们观察到深睡眠阶段时长有统计学意义的增加以及晨起头痛有所改善。UPPP组患者的多导睡眠图参数未出现显著变化。两组的咽部气道测量结果相似,并未反映出我们观察到的临床和多导睡眠图差异。
在治疗OSAHS方面,咽侧壁成形术比UPPP产生更好的临床和多导睡眠图效果,且这两种治疗方法在咽部气道横断面测量上没有差异。