日本獐牙菜的成分研究I. 关于新裂环烯醚萜二糖苷的结构

Studies on the constituents of Swertia japonica MAKINO I. On the structures of new secoiridoid diglycosides.

作者信息

Kikuchi Masafumi, Kikuchi Masao

机构信息

Tohoku Pharmaceutical University, Miyagi, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2004 Oct;52(10):1210-4. doi: 10.1248/cpb.52.1210.

DOI:10.1248/cpb.52.1210

PMID:15467237

Abstract

Eight new secoiridoid diglycosides, 6'-O-alpha-L-arabinopyranosylswertiamarin (1), 3'-O-beta-D-glucopyranosylswertiamarin (2), 4'-O-beta-D-glucopyranosylswertiamarin (3), 3'-O-beta-D-galactopyranosylswertiamarin (4), 6'-O-alpha-D-galactopyranosylswertiamarin (5), 6'-O-alpha-D-mannopyranosylswertiamarin (6), 6'-O-beta-D-fructofuranosylswertiamarin (7) and 5''-O-beta-D-glucopyranosylamaroswerin (12), were isolated, together with five known compounds from the whole plants of Swertia japonica MAKINO. The structures of the new compounds were elucidated on the basis of chemical and spectroscopic evidence. Compounds 6 and 7 are the first naturally occuring iridoid diglycosides having an alpha-D-mannopyranosyl unit and beta-D-fructofuranosyl unit, respectively.

摘要

从日本獐牙菜（Swertia japonica MAKINO）全草中分离得到8个新的裂环环烯醚萜二糖苷，即6'-O-α-L-阿拉伯吡喃糖基獐牙菜苦苷（1）、3'-O-β-D-葡萄糖吡喃糖基獐牙菜苦苷（2）、4'-O-β-D-葡萄糖吡喃糖基獐牙菜苦苷（3）、3'-O-β-D-半乳糖吡喃糖基獐牙菜苦苷（4）、6'-O-α-D-半乳糖吡喃糖基獐牙菜苦苷（5）、6'-O-α-D-甘露吡喃糖基獐牙菜苦苷（6）、6'-O-β-D-呋喃果糖基獐牙菜苦苷（7）和5''-O-β-D-葡萄糖吡喃糖基苦獐苷（12），以及5个已知化合物。通过化学和光谱数据对新化合物的结构进行了鉴定。化合物6和7分别是首次发现的天然存在的含有α-D-甘露吡喃糖基单元和β-D-呋喃果糖基单元的环烯醚萜二糖苷。