一种内体蛋白分选器的结构。
The structure of an endosomal protein sorter.
作者信息
Slagsvold Thomas, Stenmark Harald
机构信息
Department of Biochemistry, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway.
出版信息
Dev Cell. 2004 Oct;7(4):457-8. doi: 10.1016/j.devcel.2004.09.007.
PMID:15469831
Abstract
Three "endosomal sorting complexes required for transport," ESCRT-I, -II, and -III, mediate sorting of ubiquitinated membrane proteins into intraluminal endosomal vesicles that are destined for degradation in lysosomes. Two recent reports, one in Nature and one in this issue of Developmental Cell, reveal the crystal structure of the yeast form of ESCRT-II.
摘要
三种“转运所需的内体分选复合体”，即ESCRT-I、-II和-III，介导泛素化膜蛋白分选到内体腔内小泡中，这些小泡将在溶酶体中降解。最近有两篇报道，一篇发表在《自然》杂志上，另一篇发表在本期《发育细胞》杂志上，揭示了酵母形式的ESCRT-II的晶体结构。
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