过氧化物酶体增殖物激活受体激动剂对胰岛素抵抗中脂联素、肿瘤坏死因子-α及其他细胞因子有何影响？
What are the effects of peroxisome proliferator-activated receptor agonists on adiponectin, tumor necrosis factor-alpha, and other cytokines in insulin resistance?
作者信息
Boyle Patrick J
机构信息
University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA.
出版信息
Clin Cardiol. 2004 Jul;27(7 Suppl 4):IV11-6. doi: 10.1002/clc.4960271604.
Abstract
Patients with type 2 diabetes are at high risk of cardiovascular disease. In addition to treating hyperglycemia, the thiazolidinedione (TZD) class of antidiabetic agents may also benefit the cardiovascular complications associated with the disease. The two available TZDs, pioglitazone and rosiglitazone, are peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists that influence gene expression of key proteins involved in regulating glucose and lipid metabolism. Tumor necrosis factor-alpha (TNF-alpha) and adiponectin are believed to be important in the development of insulin resistance and atherosclerosis. Understanding the role of these cytokines in the inflammatory processes that trigger plaque development might lead to identification of other potential mechanisms that could be exploited to enhance future treatments for patients with diabetes and atherosclerosis.
摘要
2型糖尿病患者患心血管疾病的风险很高。除了治疗高血糖外，噻唑烷二酮（TZD）类抗糖尿病药物可能也有益于该疾病相关的心血管并发症。现有的两种TZD药物，吡格列酮和罗格列酮，都是过氧化物酶体增殖物激活受体γ（PPAR-γ）激动剂，它们会影响参与调节葡萄糖和脂质代谢的关键蛋白的基因表达。肿瘤坏死因子-α（TNF-α）和脂联素被认为在胰岛素抵抗和动脉粥样硬化的发展过程中起着重要作用。了解这些细胞因子在引发斑块形成的炎症过程中的作用，可能会有助于识别其他潜在机制，从而用于改进未来对糖尿病和动脉粥样硬化患者的治疗。
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