Synthesis and anti-inflammatory activity of derivatives of 5-[(2-disubstitutedamino-6-methyl-pyrimidin-4-yl)-sulfanylmethyl]-3H-1,3,4-oxadiazole-2-thiones.

作者信息

Burbuliene Milda Malvina, Jakubkiene Virginija, Mekuskiene Giedrute, Udrenaite Emilija, Smicius Romualdas, Vainilavicius Povilas

机构信息

Department of Organic chemistry, Faculty of Chemistry, Vilnius University, Naugarduko 24, LT-03225, Vilnius, Lithuania.

出版信息

Farmaco. 2004 Oct;59(10):767-74. doi: 10.1016/j.farmac.2004.05.007.

DOI:10.1016/j.farmac.2004.05.007

PMID:15474053

Abstract

Synthesis and results of anti-inflammatory activity in vivo of 5-[(2-disubstitutedamino-6-methyl-pyrimidin-4-yl)-sulfanylmethyl]-3H-1,3,4-oxadiazole-2-thiones and their S-alkyl-, N(3)-acyl- and N(3)-aminomethyl derivatives are described. All the tested compounds possess anti-inflammatory activity comparable to that of acetylsalicylic acid and some derivatives of 5-[(6-methyl-2-piperidin-1-yl-pyrimidin-4-yl)-sulfanylmethyl]-3H-1,3,4-oxadiazole-2-thione were found to be much more active than ibuprofen.

摘要