Post S, Kunhardt M, Sido B, Schürmann G, Herfarth C
Chirurgische Universitätsklinik Heidelberg.
Chirurg. 1992 Jan;63(1):35-8.
The effect of perioperative blood transfusions on recurrence has been investigated in 261 patients with Crohn's disease who underwent a "curative" operation since 1981. Reoperations were necessary with a rate of approximately 3% per year. By Kaplan-Meier-analysis no difference could be detected between 120 patients with transfusion and 141 without (p = 0.407, log rank test). Statistical analysis of potentially interfering covariables revealed a significant effect of age and type of operation on postoperative recurrences. Even after stratification for these parameters it was impossible to confirm the protective influence of transfusions reported by others. However, in some subgroups there was a trend towards an association of blood transfusions with earlier reoperations.
自1981年以来,对261例接受“根治性”手术的克罗恩病患者进行了围手术期输血对复发影响的研究。再次手术的必要性约为每年3%。通过Kaplan-Meier分析,120例接受输血的患者和141例未接受输血的患者之间未发现差异(p = 0.407,对数秩检验)。对潜在干扰协变量的统计分析显示,年龄和手术类型对术后复发有显著影响。即使对这些参数进行分层后,也无法证实其他人所报告的输血的保护作用。然而,在一些亚组中,输血与早期再次手术之间存在关联趋势。