新型自由基清除剂依达拉奉对吸烟者内皮依赖性血管舒张功能的影响。
Effect of edaravone, a novel free radical scavenger, on endothelium-dependent vasodilation in smokers.
作者信息
Jitsuiki Daisuke, Higashi Yukihito, Goto Chikara, Kimura Masashi, Noma Kensuke, Hara Keiko, Nakagawa Keigo, Oshima Tetsuya, Chayama Kazuaki, Yoshizumi Masao
机构信息
Department of Cardiovascular Physiology and Medicine, Hiroshima University, Hiroshima, Japan.
出版信息
Am J Cardiol. 2004 Oct 15;94(8):1070-3. doi: 10.1016/j.amjcard.2004.06.072.
The forearm blood flow (FBF) responses to acetylcholine and to sodium nitroprusside were evaluated before and after administration of edaravone in 10 smokers and 10 nonsmokers. FBF response to acetylcholine was lower in smokers than in nonsmokers. The vasodilatory effects of sodium nitroprusside were similar in both groups. Co-infusion of edaravone increased the FBF response to acetylcholine in smokers, but did not affect the FBF response to acetylcholine in nonsmokers. The administration of N(G)-monomethyl-l-arginine abolished edaravone-induced augmentation of the FBF response to acetylcholine in smokers. The antioxidative agent edaravone increases nitric oxide mediated vasodilation through a decrease in oxidative stress.
在10名吸烟者和10名非吸烟者中，评估了依达拉奉给药前后前臂血流量（FBF）对乙酰胆碱和硝普钠的反应。吸烟者对乙酰胆碱的FBF反应低于非吸烟者。两组中硝普钠的血管舒张作用相似。依达拉奉联合输注增加了吸烟者对乙酰胆碱的FBF反应，但不影响非吸烟者对乙酰胆碱的FBF反应。N（G）-单甲基-L-精氨酸的给药消除了依达拉奉诱导的吸烟者对乙酰胆碱的FBF反应增强。抗氧化剂依达拉奉通过降低氧化应激增加一氧化氮介导的血管舒张。
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