尾加压素II在外周组织中作为自分泌/旁分泌生长因子的作用。

Role of urotensin II in peripheral tissue as an autocrine/paracrine growth factor.

作者信息

Yoshimoto Takanobu, Matsushita Mika, Hirata Yukio

机构信息

Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo 113-8519, Japan.

出版信息

Peptides. 2004 Oct;25(10):1775-81. doi: 10.1016/j.peptides.2004.03.028.

DOI:10.1016/j.peptides.2004.03.028

PMID:15476945

Abstract

Urotensin II (UII), originally isolated from goby urophysis, has been shown to be an endogenous ligand for an orphan G-protein-coupled receptor, GPR14. Recent development of PCR quantitative method revealed that UII and UT receptor (GPR14) were expressed in a broad range of tissues and organs, including cardiovascular and renal system, and assumed to function as an autocrine/paracrine factor. UII is a potent vasoconstrictor peptide, whose potency is greater than any other vasoconstrictors thus far known. However, its physiological roles have been found to extend far beyond the regulation of vascular tone. In this review, we focused on the mitogenic action of UII and discuss its underlying cellular mechanisms and potential physiological/pathophysiological role in various human diseases.

摘要

尾加压素II（UII）最初是从虾虎鱼的尾垂体中分离出来的，现已证明它是一种孤儿G蛋白偶联受体GPR14的内源性配体。PCR定量方法的最新进展表明，UII和UT受体（GPR14）在包括心血管和肾脏系统在内的广泛组织和器官中表达，并被认为作为自分泌/旁分泌因子发挥作用。UII是一种强效的血管收缩肽，其效力大于迄今为止已知的任何其他血管收缩剂。然而，已发现其生理作用远远超出血管张力的调节。在本综述中，我们重点关注UII的促有丝分裂作用，并讨论其潜在的细胞机制以及在各种人类疾病中的潜在生理/病理生理作用。