基于DNA构象变化对DNA指导的反应进行重编程。
Reprogramming DNA-directed reactions on the basis of a DNA conformational change.
作者信息
Chen Yi, Mao Chengde
机构信息
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
出版信息
J Am Chem Soc. 2004 Oct 20;126(41):13240-1. doi: 10.1021/ja045718j.
PMID:15479075
Abstract
A strategy has been developed for switching chemical reactions between two identical reagents on the basis of DNA duplex-triplex transition. In response to the change of solution pH, a DNA complex changes its conformation and repositions chemical reagents that are conjugated with DNA strands. As a result, chemical reactions are reprogrammed. This strategy is expected to be applicable to sophisticated chemical syntheses.
摘要
基于DNA双链-三链转变，已开发出一种在两种相同试剂之间切换化学反应的策略。响应溶液pH的变化，DNA复合物改变其构象并重新定位与DNA链共轭的化学试剂。结果，化学反应被重新编程。该策略有望应用于复杂的化学合成。
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