克兰费尔特综合征患者的辅助生殖技术：一项批判性综述。
Assisted reproductive techniques in patients with Klinefelter syndrome: a critical review.
作者信息
Denschlag Dominik, Tempfer Clemens, Kunze Myriam, Wolff Gerhard, Keck Christoph
机构信息
Department of Obstetrics and GynecologyUniversity of Freiburg, Freiburg, Germany.
出版信息
Fertil Steril. 2004 Oct;82(4):775-9. doi: 10.1016/j.fertnstert.2003.09.085.
OBJECTIVE
To summarize the existing experience with the use and success rate of assisted reproductive techniques (ART), in particular testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI), in Klinefelter patients.
DESIGN
A systematic review of the literature, including all published case reports to date.
PATIENT(S): Thirty-nine reported successful pregnancies fathered by nonmosaic Klinefelter patients.
MAIN OUTCOME MEASURE(S): The overall risk of transmitting a chromosomal abnormality to the offspring of Klinefelter patients.
RESULT(S): In nonmosaic and mosaic Klinefelter patients, chromosomally normal sperm cells can be extracted from testicular tissue and used for ICSI.
CONCLUSION(S): The application of ART to Klinefelter patients can be recommended as a method to achieve reproduction in this selected infertility patient cohort.
目的
总结克氏综合征患者使用辅助生殖技术（ART），特别是睾丸精子提取术（TESE）和卵胞浆内单精子注射术（ICSI）的现有经验及成功率。
设计
对文献进行系统回顾，包括迄今为止所有已发表的病例报告。
患者
39例由非嵌合型克氏综合征患者孕育的成功妊娠报告。
主要观察指标
克氏综合征患者将染色体异常遗传给后代的总体风险。
结果
在非嵌合型和嵌合型克氏综合征患者中，可从睾丸组织中提取染色体正常的精子细胞并用于ICSI。
结论
可推荐对克氏综合征患者应用ART，作为在这一特定不育患者群体中实现生育的一种方法。
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