Id3基因敲除小鼠作为干燥综合征的新模型：仅是T细胞缺陷还是另有其他？
Id3 knockout mice as a new model for sjogren's syndrome: only a T cell defect or more?
作者信息
Versnel Marjan A
机构信息
Department Immunology, Erasmus MC, Rotterdam, The Netherlands.
出版信息
Immunity. 2004 Oct;21(4):457-8. doi: 10.1016/j.immuni.2004.10.003.
PMID:15485622
Abstract
Id3(-/-) mice were found to have autoantibodies, lymphocytic infiltrates in, and decreased secretion by exocrine glands. Similar symptoms are found in primary Sjogren's Syndrome. In this issue of Immunity, Li and colleagues suggest an important role for Id3 function in T cell development and Sjogren's Syndrome.
摘要
研究发现，Id3基因敲除小鼠体内存在自身抗体、淋巴细胞浸润，且外分泌腺分泌减少。原发性干燥综合征也有类似症状。在本期《免疫》杂志中，李及其同事指出Id3功能在T细胞发育和干燥综合征中发挥重要作用。
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