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肥胖症患者接受开放式和腹腔镜胃旁路手术后住院时间延长的预测因素:体重指数、手术时长、睡眠呼吸暂停、哮喘和代谢综合征。

Predictors of prolonged hospital stay following open and laparoscopic gastric bypass for morbid obesity: body mass index, length of surgery, sleep apnea, asthma, and the metabolic syndrome.

作者信息

Ballantyne Garth H, Svahn Jonathan, Capella Rafael F, Capella Joseph F, Schmidt Hans J, Wasielewski Annette, Davies Richard J

机构信息

Bariatric Surgery Center, Hackensack University Medical Center, NJ 07601, USA.

出版信息

Obes Surg. 2004 Sep;14(8):1042-50. doi: 10.1381/0960892041975460.

Abstract

BACKGROUND

The number of weight reduction operations performed for type II and type III obesity is rapidly escalating. Risk of surgery has been infrequently stratified for patient subgroups. The purpose of this study was to identify patient characteristics that increased the odds of a prolonged hospital length of stay (LOS) following open or laparoscopic Roux-en-Y gastric bypass (RYGBP).

METHODS

The hospital records of 311 patients who underwent RYGBP in a 6-month period were retrospectively reviewed. Patient characteristics including the presence of significant obesity-related medical conditions were recorded. Analysis was based on intent to treat. Univariate and step-wise logistic regression analysis was used to identify the odds ratio (OR) and adjusted odds ratio (AOR) for predictors of an increased hospital LOS.

RESULTS

Datasets for 311 patients were complete.159 patients underwent open vertical banded gastro-plasty-Roux-en-Y gastric bypass (VBG-RYGBP) and152 laparoscopic RYGBP (LRYGBP). 78% of patients were female. Median age was 40 years (range 18-68). Median BMI was 49 kg/m2 (range 35-82). 17% of patients had sleep apnea, 18% asthma, 19% type 2 diabetes, 13% hypercholesterolemia and 44% hypertension. Median length of surgery for open VBG-RYGBP (64 minutes) was significantly faster than forLRYGBP (105 minutes). Median length of stay was significantly shorter for LRYGBP (2 days) than openVBG-RYGBP (3 days). Univariate logistic regression analysis identified 6 predictors of increased LOS:open surgery (0.4 OR); increasing BMI (60 kg/m2 0.38 OR; BMI 70 kg/m2 0.53 OR); increasing length of surgery (120 min 0.33 OR; 180 min 0.48 OR); sleep apnea (2.25 OR); asthma (3.73 OR); and hypercholesterolemia (3.73 OR). Subset analysis identified patients with the greatest odds for a prolonged hospital stay: women with asthma (2.47 AOR) or coronary artery disease (8.65 AOR); men with sleep apnea (5.54 OR) or the metabolic syndrome (6.67-10.20 OR); and patients undergoing a laparoscopic operation with sleep apnea (11.53 AOR) or coronary artery disease(12.15 AOR).

CONCLUSIONS

Open surgery, BMI, length of surgery,sleep apnea, asthma and hypercholesterolemia all increased the odds of a prolonged LOS. Patients with the greatest odds of long LOS were women with asthma or coronary disease, men with sleep apnea or the metabolic syndrome, and patients undergoing laparoscopic surgery with sleep apnea or coronary artery disease. Patients at high-risk for prolonged hospital stay can be identified before undergoingRYGBP. Surgeons may wish to avoid high-risk patients early in their bariatric surgery experience.

摘要

背景

针对II型和III型肥胖症实施的减重手术数量正在迅速增加。手术风险很少针对患者亚组进行分层。本研究的目的是确定那些会增加开腹或腹腔镜Roux-en-Y胃旁路术(RYGBP)后住院时间延长几率的患者特征。

方法

回顾性分析了311例在6个月内接受RYGBP手术患者的医院记录。记录患者特征,包括是否存在与肥胖相关的严重疾病。分析基于意向性治疗原则。采用单因素和逐步逻辑回归分析来确定住院时间延长预测因素的比值比(OR)和调整后比值比(AOR)。

结果

311例患者的数据集完整。159例患者接受了开腹垂直捆绑胃成形术-Roux-en-Y胃旁路术(VBG-RYGBP),152例接受了腹腔镜RYGBP(LRYGBP)。78%的患者为女性。中位年龄为40岁(范围18 - 68岁)。中位体重指数(BMI)为49kg/m²(范围35 - 82)。17%的患者有睡眠呼吸暂停,18%有哮喘,19%有2型糖尿病,13%有高胆固醇血症,44%有高血压。开腹VBG-RYGBP的中位手术时间(64分钟)显著快于LRYGBP(105分钟)。LRYGBP的中位住院时间(2天)显著短于开腹VBG-RYGBP(3天)。单因素逻辑回归分析确定了6个住院时间延长的预测因素:开腹手术(OR为0.4);BMI增加(BMI为60kg/m²时OR为0.38;BMI为70kg/m²时OR为0.53);手术时间延长(手术时间120分钟时OR为0.33;180分钟时OR为0.48);睡眠呼吸暂停(OR为2.25);哮喘(OR为3.73);高胆固醇血症(OR为3.73)。亚组分析确定了住院时间延长几率最高的患者:患有哮喘(AOR为2.47)或冠状动脉疾病(AOR为8.65)的女性;患有睡眠呼吸暂停(OR为5.54)或代谢综合征(OR为6.67 - 10.20)的男性;以及接受腹腔镜手术且患有睡眠呼吸暂停(AOR为11.53)或冠状动脉疾病(AOR为12.15)的患者。

结论

开腹手术、BMI、手术时间、睡眠呼吸暂停、哮喘和高胆固醇血症均增加了住院时间延长的几率。住院时间延长几率最高的患者是患有哮喘或冠状动脉疾病的女性、患有睡眠呼吸暂停或代谢综合征的男性,以及接受腹腔镜手术且患有睡眠呼吸暂停或冠状动脉疾病的患者。在接受RYGBP手术前可以识别出住院时间延长的高危患者。外科医生在其减重手术经验早期可能希望避免选择高危患者。

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