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尼日利亚乔斯地区新诊断2型糖尿病患者微量白蛋白尿的患病率

Prevalence of microalbuminuria in newly diagnosed type 2 diabetic patients in Jos Nigeria.

作者信息

Agaba E I, Agaba P A, Puepet F H

机构信息

Department of Medicine, Jos University Teaching Hospital, Jos, Nigeria.

出版信息

Afr J Med Med Sci. 2004 Mar;33(1):19-22.

Abstract

Diabetic nephropathy contributes significantly to end-stage renal disease in Nigeria. The earliest clinically detectable stage is that of microalbuminuria when interventions could halt or retard the progression to end-stage renal disease. To investigate the prevalence of microalbuminuria in newly diagnosed type 2 diabetic patients and its clinical correlates in Jos, consecutive patients with newly diagnosed type 2 diabetes attending two large hospitals in Jos were evaluated at three different occasions of monthly intervals for microalbuminuria using Micral test strips 11. Patients with proteinuria, positive nitrite test/ urine microbial culture, acute illnesses or cardiac decompensation were excluded. Out of a total of 99 patients recruited, only 65 completed the study. Microalbuminuria was present in 32(49.2%) of the patients, and was significantly associated with mean arterial pressure, systemic hypertension and diabetic retinopathy (P < 0.05). Microalbuminuria is common in newly diagnosed patients with type 2 diabetes mellitus. Our finding supports routine screening for microalbuminuria as part of the initial evaluation of these patients.

摘要

在尼日利亚,糖尿病肾病是终末期肾病的重要病因。临床上最早可检测到的阶段是微量白蛋白尿期,此时采取干预措施可阻止或延缓疾病进展至终末期肾病。为了调查乔斯地区新诊断的2型糖尿病患者微量白蛋白尿的患病率及其临床相关性,我们对在乔斯两家大型医院就诊的连续新诊断2型糖尿病患者,每隔一个月在三个不同时间点使用Micral试纸条评估微量白蛋白尿情况 11。排除蛋白尿、亚硝酸盐试验阳性/尿微生物培养阳性、急性疾病或心脏失代偿患者。在总共招募的99例患者中,只有65例完成了研究。32例(49.2%)患者存在微量白蛋白尿,且与平均动脉压、系统性高血压和糖尿病视网膜病变显著相关(P < 0.05)。微量白蛋白尿在新诊断的2型糖尿病患者中很常见。我们的研究结果支持对这些患者进行常规微量白蛋白尿筛查,作为初始评估的一部分。

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