帕金森病中全脑基于体素的区域脑血流量与智商评分之间的相关性分析。
Whole-brain voxel-based correlation analysis between regional cerebral blood flow and intelligence quotient score in Parkinson's disease.
作者信息
Oishi Kenichi, Ogawa Masafumi, Oya Yasushi, Kawai Mitsuru
机构信息
Department of Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Japan.
出版信息
Eur Neurol. 2004;52(3):151-5. doi: 10.1159/000081624. Epub 2004 Oct 18.
The correlation between regional cerebral blood flow (rCBF) and intelligence quotient (IQ) score was investigated in patients with Parkinson's disease (PD) without severe dementia. We analyzed the (9mTc-ethyl cysteinate dimer single-photon emission computed tomography quantitative images and Revised Wechsler Adult Intelligence Scale scores of 44 PD patients using statistical parametric mapping. Verbal IQ positively correlated with rCBF in the right ventral striatum and the bilateral prefrontal cortex, performance IQ positively correlated with rCBF in the right operculum, insula and the left middle temporal gyrus, and full-scale IQ positively correlated with rCBF in the right operculum, insula and the ventral striatum. The identified areas may be functionally related to mild to moderate cognitive impairment in patients with PD.
在无严重痴呆的帕金森病（PD）患者中，研究了局部脑血流量（rCBF）与智商（IQ）得分之间的相关性。我们使用统计参数映射分析了44例PD患者的（9mTc-乙基半胱氨酸二聚体单光子发射计算机断层扫描定量图像和修订的韦氏成人智力量表得分。言语智商与右侧腹侧纹状体和双侧前额叶皮质的rCBF呈正相关，操作智商与右侧额下回、岛叶和左侧颞中回的rCBF呈正相关，全量表智商与右侧额下回、岛叶和腹侧纹状体的rCBF呈正相关。所确定的区域可能在功能上与PD患者的轻度至中度认知障碍有关。
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