白细胞介素-27受体（WSX-1）是2型免疫的先天性和适应性成分的抑制剂。
The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity.
作者信息
Artis David, Villarino Alejandro, Silverman Michael, He Weimian, Thornton Elizabeth M, Mu Sharon, Summer Shamin, Covey Todd M, Huang Elaine, Yoshida Hiroki, Koretzky Gary, Goldschmidt Michael, Wu Gary D, de Sauvage Fred, Miller Hugh R P, Saris Christiaan J M, Scott Phillip, Hunter Christopher A
机构信息
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
J Immunol. 2004 Nov 1;173(9):5626-34. doi: 10.4049/jimmunol.173.9.5626.
Although previous studies have investigated the role of IL-27/WSX-1 interactions in the regulation of Th1 responses, little is known about their role in regulating Th2-type responses. Studies presented in this work identify a direct role for IL-27/WSX-1 interactions in the negative regulation of type 2 responses independent of effects on type 1 cytokines. WSX-1-/- mice infected with the gastrointestinal helminth Trichuris muris displayed accelerated expulsion of parasites and the development of exaggerated goblet cell hyperplasia and mastocytosis in the gut due to increased production of Th2 cytokines. Enhanced mast cell activity in the absence of WSX-1 was consistent with the ability of wild-type mast cells to express this receptor. In addition, IL-27 directly suppressed CD4+ T cell proliferation and Th2 cytokine production. Together, these studies identify a novel role for IL-27/WSX-1 in limiting innate and adaptive components of type 2 immunity at mucosal sites.
尽管先前的研究已经探究了IL-27/WSX-1相互作用在调节Th1反应中的作用，但对于它们在调节Th2型反应中的作用却知之甚少。本研究表明，IL-27/WSX-1相互作用在2型反应的负调节中具有直接作用，且独立于对1型细胞因子的影响。感染胃肠道蠕虫毛首鞭形线虫的WSX-1基因敲除小鼠，由于Th2细胞因子产生增加，寄生虫排出加速，肠道杯状细胞增生和肥大细胞增多加剧。在缺乏WSX-1的情况下，肥大细胞活性增强，这与野生型肥大细胞表达该受体的能力一致。此外，IL-27直接抑制CD4+ T细胞增殖和Th2细胞因子产生。这些研究共同确定了IL-27/WSX-1在限制黏膜部位2型免疫的固有和适应性成分方面的新作用。
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