Similowski Thomas, Cracco Christophe, Duguet Alexandre, Derenne Jean-Philippe
Service de pneumologie et réanimation, groupe hospitalier La Pitié-Salpêtrière, 75651 Paris 13.
Rev Prat. 2004 Sep 15;54(13):1438-44.
Acute episode of chronic obstructive pulmonary disease occurs in almost all patients, during which cough, expectoration and dyspnea increase. When the underlying disease is not severe and the acute episode not life-threatening, the term "exacerbation" is appropriate, and the patients can be managed at home. When the underlying disease is advanced and the acute episode possibly life-threatening, the terms of "acute respiratory failure" or "decompensation" can be used. These patients are most often admitted to the hospital, and at times to the intensive care unit. Bronchodilators and respiratory physiotherapy form the basis of the management of acute episodes of COPD. In severe cases, oxygen must be administered, and the decision of an hospitalisation considered. Antibiotics and corticosteroids shoud not be prescribed in a systematic manner. In the most severe cases, non-invasive ventilation must be accessible. The prevention of acute episodes of COPD is best achieved through tobacco cessation and influenza vaccine. Finally, an acute episode may be an opportunity to make a diagnosis of COPD if this has not been done before.
几乎所有慢性阻塞性肺疾病患者都会出现急性发作,发作期间咳嗽、咳痰及呼吸困难加重。当基础疾病不严重且急性发作不危及生命时,使用“加重”一词恰当,患者可居家治疗。当基础疾病严重且急性发作可能危及生命时,可使用“急性呼吸衰竭”或“失代偿”等术语。这些患者大多需住院治疗,有时还需入住重症监护病房。支气管扩张剂和呼吸物理治疗是慢性阻塞性肺疾病急性发作治疗的基础。在严重情况下,必须给予吸氧,并考虑是否住院。抗生素和皮质类固醇不应常规使用。在最严重的情况下,必须具备无创通气条件。预防慢性阻塞性肺疾病急性发作的最佳方法是戒烟和接种流感疫苗。最后,如果之前未诊断出慢性阻塞性肺疾病,急性发作可能是确诊的契机。