一种来自巴拿马番荔枝的新型抗菌中氮茚生物碱。

A novel antimicrobial indolizinium alkaloid from Aniba panurensis.

作者信息

Klausmeyer Paul, Chmurny Gwendolyn N, McCloud Thomas G, Tucker Kenneth D, Shoemaker Robert H

机构信息

Natural Products Support Group, Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc, National Cancer Institute-Frederick, Maryland 21702-1201, USA.

出版信息

J Nat Prod. 2004 Oct;67(10):1732-5. doi: 10.1021/np040114e.

DOI:10.1021/np040114e

PMID:15497951

Abstract

Activity-guided fractionation of an Aniba panurensis organic solvent extract has led to the isolation of the novel alkaloid 6,8-didec-(1Z)-enyl-5,7-dimethyl-2,3-dihydro-1H-indolizinium, as the trifluoroacetic acid salt (1). Its structure was determined by NMR and mass spectrometry. Bioassays performed in vitro demonstrated toxicity of compound 1 to a drug-resistant strain of Candida albicans.

摘要

对圭亚那黄肉楠（Aniba panurensis）有机溶剂提取物进行活性导向分级分离，得到了新型生物碱6,8 - 二癸 -（1Z）- 烯基 - 5,7 - 二甲基 - 2,3 - 二氢 - 1H - 中氮茚鎓三氟乙酸盐（1）。其结构通过核磁共振（NMR）和质谱测定。体外生物测定表明化合物1对白色念珠菌的耐药菌株具有毒性。