2-(4-甲氧基苯氧基)-5-硝基-N-(4-氨磺酰基苯基)苯甲酰胺激活Kir6.2/SUR1 K(ATP)通道。
2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 K(ATP) channels.
作者信息
Nielsen Flemming E, Jacobsen Palle, Worsaae Anne, Arkhammar Per O G, Wahl Philip, Bondo Hansen John
机构信息
Discovery, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Måløv, Denmark.
出版信息
Bioorg Med Chem Lett. 2004 Dec 6;14(23):5727-30. doi: 10.1016/j.bmcl.2004.09.057.
PMID:15501029
Abstract
2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide and close analogues inhibit glucose stimulated insulin release through activation of Kir6.2/SUR1 K(ATP) channels of beta cells.
摘要
2-(4-甲氧基苯氧基)-5-硝基-N-(4-氨磺酰基苯基)苯甲酰胺及其类似物通过激活β细胞的Kir6.2/SUR1 K(ATP)通道抑制葡萄糖刺激的胰岛素释放。
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