山东省汉族人群中CYP11B2基因-344T/C多态性与原发性高血压的相关性
Associations between CYP11B2 gene -344T/C polymorphism and essential hypertension in the Han nationality in Shandong province.
作者信息
Sun Xiao-jian, Hou Xiao-fei, Liu Shao-rong, Liu Wen-bo, Tao Zhi-gang, Li Jian-yuan
机构信息
Department of Cardiology, Yuhuangding Hospital of Qingdao University, Yantai, Shandong, PR China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004 Oct;21(5):502-4.
OBJECTIVE
To investigate whether the -344T/C polymorphism of CYP11B2 gene is associated with essential hypertension in the Hans in Shandong province.
METHODS
Plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were measured with radioimmunoassays; the hypertensives were classified as low-renin and normal- or high-renin group by PAC/PRA ratio. -344T/C polymorphism was determined by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) in controls and hypertensives.
RESULTS
No significant differences were found in genotype distribution or allele frequency between groups of control and primary hypertension or between groups of control and normal- or high-renin hypertension. The C allele frequency in low-renin hypertension group was significantly higher than that in normotensives and normal- or high-renin hypertension group (P < 0.05).
CONCLUSION
These results suggest that -344T/C polymorphism of CYP11B2 gene may be associated with low-renin essential hypertension in the Han nationality in Shandong province.
目的
探讨CYP11B2基因-344T/C多态性与山东省汉族人群原发性高血压的关系。
方法
采用放射免疫分析法测定血浆肾素活性（PRA）和血浆醛固酮浓度（PAC）；根据PAC/PRA比值将高血压患者分为低肾素组和正常或高肾素组。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）法检测对照组和高血压患者的-344T/C多态性。
结果
对照组与原发性高血压组之间或对照组与正常或高肾素性高血压组之间的基因型分布或等位基因频率无显著差异。低肾素性高血压组的C等位基因频率显著高于正常血压组和正常或高肾素性高血压组（P<0.05）。
结论
这些结果提示，CYP11B2基因-344T/C多态性可能与山东省汉族人群低肾素性原发性高血压有关。
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