Use of the mitral valve-tricuspid valve distance as a marker of fetal endocardial cushion defects.

作者信息

Bolnick Alan D, Zelop Carolyn M, Milewski Beth, Gianferrari Elisa A, Borgida Adam F, Egan James F X

机构信息

Department of Gynecology and Obstetrics, Division of Maternal-Fetal Medicine, University of Connecticut School of Medicine, Farmington, CT, USA.

出版信息

Am J Obstet Gynecol. 2004 Oct;191(4):1483-5. doi: 10.1016/j.ajog.2004.05.042.

DOI:10.1016/j.ajog.2004.05.042

PMID:15507987

Abstract

OBJECTIVE

The purpose of this study was to compare the mitral valve-tricuspid valve distance in second-trimester fetuses with normal cardiac anatomy versus those fetuses with endocardial cushion defects.

STUDY DESIGN

We identified fetuses between 16 and 24 weeks of gestation. The distance between the insertions of the medial leaflets of the mitral and tricuspid valves were obtained. Linear regression curves were generated.

RESULTS

The mean mitral valve-tricuspid valve distance for 86 fetuses with normal cardiac anatomy was 2.02 mm, compared with 0.37 mm in 13 fetuses with endocardial cushion defects ( P = .0001). Linear regression curve correlating mitral valve-tricuspid valve distance with gestational age showed a gradual slope (R 2 = 0.28; P < .0001). With a mitral valve-tricuspid valve distance < 5th percentile as a marker for the diagnosis of endocardial cushion defect gave a sensitivity of 69.2%, a specificity of 100%, a positive predictive value of 100%, a negative predictive value of 95.6%, and a false-positive rate of 0% ( P = .0001).