中枢给予神经介素U后大鼠室旁核中含促肾上腺皮质激素释放因子神经元的Fos表达
Fos expression in CRF-containing neurons in the rat paraventricular nucleus after central administration of neuromedin U.
作者信息
Yokota Makoto, Ozaki Yumi, Sakamoto Fumihiko, Yamada Seiji, Saito Jun, Fujihara Hiroaki, Ueta Yoichi
机构信息
Department of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
出版信息
Stress. 2004 Jun;7(2):109-12. doi: 10.1080/10253890410001727370.
We examined the effects of centrally administered neuromedin U (NMU) on corticotrophin-releasing factor (CRF)-containing neurons in the hypothalamic paraventricular nucleus (PVN) of rats, using double immunohistochemistry for CRF and Fos. Almost all CRF-containing neurons in the parvocellular divisions of the PVN expressed Fos-like immunoreactivity 90 min after intracerebroventricular administration of NMU (3 nmol/rat). This results suggest the possibility that central NMU may be involved in stress-induced activation of CRF-containing neurons in the PVN.
我们采用促肾上腺皮质激素释放因子（CRF）和Fos的双重免疫组织化学方法，研究了向大鼠下丘脑室旁核（PVN）中脑内注射神经介素U（NMU）对含促肾上腺皮质激素释放因子（CRF）神经元的影响。脑室内注射NMU（3 nmol/大鼠）90分钟后，PVN小细胞部几乎所有含CRF的神经元均表达Fos样免疫反应性。这些结果提示，中枢NMU可能参与应激诱导的PVN中含CRF神经元的激活。
Zotero 插件