脆性X智力障碍中的RNA与微小RNA

RNA and microRNAs in fragile X mental retardation.

作者信息

Jin Peng, Alisch Reid S, Warren Stephen T

机构信息

Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.

出版信息

Nat Cell Biol. 2004 Nov;6(11):1048-53. doi: 10.1038/ncb1104-1048.

DOI:10.1038/ncb1104-1048

PMID:15516998

Abstract

Fragile X syndrome is caused by the loss of an RNA-binding protein called FMRP (for fragile X mental retardation protein). FMRP seems to influence synaptic plasticity through its role in mRNA transport and translational regulation. Recent advances include the identification of mRNA ligands, FMRP-mediated mRNA transport and the neuronal consequence of FMRP deficiency. FMRP was also recently linked to the microRNA pathway. These advances provide mechanistic insight into this disorder, and into learning and memory in general.

摘要

脆性X综合征是由一种名为FMRP（脆性X智力低下蛋白）的RNA结合蛋白缺失引起的。FMRP似乎通过其在mRNA运输和翻译调控中的作用来影响突触可塑性。最近的进展包括mRNA配体的鉴定、FMRP介导的mRNA运输以及FMRP缺乏的神经元后果。FMRP最近还与微小RNA途径相关联。这些进展为这种疾病以及一般的学习和记忆提供了机制上的见解。