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[炭疽——对人类和动物的持续威胁]

[Anthrax--continuous threat to humans and animals].

作者信息

Mizak Lidia

机构信息

Ośrodek Diagnostyki i Zwalczania Zagrozeń Biologicnych, Wojskowy Instytut Higieny i Epidemiologii w Puławach.

出版信息

Przegl Epidemiol. 2004;58(2):335-42.

Abstract

Gram-positive, spore-forming, aerobic bacterium Bacillus anthracis is an etiological agent of anthrax a disease very dangerous to humans and all warm-blooded animals. The spore forms are markedly resistant to unfavourable environmental extremes of heat, cold, desiccation, chemicals, irradiation etc. The vegetative forms characterised virulence factors: the antiphagocytic poly-gamma-D-polipeptide capsule and three proteins, edema factor (EF), lethal factor (LF) and protective antigen (PA). Anthrax is mainly transmitted from animals to man through food of animal origin, animal products and contamination of the environment with B. anthracis and its spores. There are three types of this disease: cutaneous, intestinal and inhalation anthrax. Research on anthrax as a biological weapon began more then 80 years ago. Depending on the target chosen and the scale of the attack the anthrax spores may by used to contaminate of foodstuffs or liquids and water. The aerosolised release of anthrax spore can cause illness with a high fatality rate.

摘要

革兰氏阳性、形成芽孢的需氧细菌炭疽芽孢杆菌是炭疽病的病原体,炭疽病对人类和所有温血动物来说是一种非常危险的疾病。芽孢形式对高温、低温、干燥、化学物质、辐射等不利的极端环境具有显著的抗性。营养形式具有毒力因子:抗吞噬的多聚-γ-D-多肽荚膜和三种蛋白质,即水肿因子(EF)、致死因子(LF)和保护性抗原(PA)。炭疽主要通过动物源性食物、动物产品以及炭疽芽孢杆菌及其芽孢对环境的污染从动物传播给人类。这种疾病有三种类型:皮肤炭疽、肠炭疽和吸入性炭疽。对炭疽作为生物武器的研究始于80多年前。根据所选目标和攻击规模,炭疽芽孢可用于污染食品、液体和水。炭疽芽孢的气溶胶释放可导致高死亡率的疾病。

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