血管紧张素转换酶抑制剂对预防心肌梗死的类效应。

Class effect of angiotensin-converting enzyme inhibitors on prevention of myocardial infarction.

作者信息

Sauer William H, Baer Jefferson T, Berlin Jesse A, Kimmel Stephen E

机构信息

Cardiovascular Division, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA.

出版信息

Am J Cardiol. 2004 Nov 1;94(9):1171-3. doi: 10.1016/j.amjcard.2004.07.087.

DOI:10.1016/j.amjcard.2004.07.087

PMID:15518614

Abstract

Angiotensin-converting enzyme (ACE) inhibitors differ in their affinity for tissue-bound ACE. It has been hypothesized that tissue ACE affinity might be responsible for some of the beneficial cardiovascular properties of ACE inhibitors. The present study examined this question and found no correlation between tissue ACE affinity and risk of first nonfatal myocardial infarction in patients who have hypertension.

摘要

血管紧张素转换酶（ACE）抑制剂对组织结合型ACE的亲和力各不相同。据推测，组织ACE亲和力可能是ACE抑制剂某些有益心血管特性的原因。本研究对这一问题进行了探讨，结果发现，在高血压患者中，组织ACE亲和力与首次非致命性心肌梗死风险之间并无关联。