de Curtis Marco, Paré Denis
Department of Experimental Neurophysiology, Istituto Nazionale Neurologico, Via Celoria 11, 20133 Milan, Italy.
Prog Neurobiol. 2004 Oct;74(2):101-10. doi: 10.1016/j.pneurobio.2004.08.005.
Anatomical data indicate that the parahippocampal region, comprised of the perirhinal (PRC), postrhinal (POR) and entorhinal (ERC) cortices, is an essential link between neocortex and hippocampus. Lesion studies demonstrated that memory functions previously ascribed to the hippocampus depend on the integrity of the rhinal cortices. This review will consider recent data suggesting that the ERC and PRC, far from being passive relay stations, actively gate impulse traffic between neocortex and hippocampus, because they are endowed with a powerful intrinsic inhibitory system. It is proposed that the cross-talk between PRC and ERC is not organized to unrestrictedly transfer information, but to select relevant inputs. The implication of these new evidences for the propagation of epileptiform activity will be considered.
解剖学数据表明，海马旁区域由嗅周皮质（PRC）、嗅后皮质（POR）和内嗅皮质（ERC）组成，是新皮质与海马体之间的重要连接。损伤研究表明，先前归因于海马体的记忆功能依赖于嗅周皮质的完整性。本综述将探讨近期数据，这些数据表明，ERC和PRC远非被动中继站，而是通过其强大的内在抑制系统，积极控制新皮质与海马体之间的冲动传递。研究表明，PRC和ERC之间的相互作用并非无限制地传递信息，而是选择相关输入。本文还将考虑这些新证据对癫痫样活动传播的影响。
