人体外受精早期妊娠中的胎盘蛋白14

Placental protein 14 in human in-vitro fertilization early pregnancies.

作者信息

Nylund L, Gustafson O, Lindblom B, Pousette A, Seppälä M, Riittinen L, Akerlöf E

机构信息

Department of Obstetrics and Gynaecology, Karolinska Institute, Huddinge University Hospital, Sweden.

出版信息

Hum Reprod. 1992 Jan;7(1):128-30. doi: 10.1093/oxfordjournals.humrep.a137546.

DOI:10.1093/oxfordjournals.humrep.a137546

PMID:1551949

Abstract

Placental protein 14 (PP14) and human chorionic gonadotrophin (HCG) were analysed in patients participating in an in-vitro fertilization-embryo transfer programme which did not include any kind of luteal support. Women with normal pregnancies, spontaneous abortions, ectopic pregnancies, biochemical pregnancies and non-pregnant women were compared. A combination of HCG and PP14 analyses distinguished between normal and abnormal implantation as early as 15 days after oocyte retrieval. The product of HCG (IU/l) and PP14 (micrograms/l) concentrations differed significantly between normal pregnancy, spontaneous abortion and ectopic pregnancy (P = 0.0248). It is concluded that both endometrial (PP14) and trophoblastic (HCG) markers, when used in combination, exhibit changes in abnormal implantation which may be clinically useful.

摘要

对参与一项不包括任何黄体支持的体外受精-胚胎移植项目的患者进行了胎盘蛋白14（PP14）和人绒毛膜促性腺激素（HCG）分析。比较了正常妊娠、自然流产、异位妊娠、生化妊娠的女性以及未妊娠女性。早在取卵后15天，HCG和PP14分析相结合就能区分正常和异常着床。正常妊娠、自然流产和异位妊娠之间，HCG（国际单位/升）和PP14（微克/升）浓度的乘积差异显著（P = 0.0248）。结论是，子宫内膜标志物（PP14）和滋养层标志物（HCG）联合使用时，在异常着床时会出现变化，这可能具有临床应用价值。