Hamaguchi-Hamada Kayoko, Hamada Shun, Yagi Takeshi
KOKORO Biology Group, Laboratories for Integrated Biology, Graduate School of Frontier Biosciences, Osaka University, Yamadaoka 1-3, Suita, 565-0871, Japan.
Brain Res Mol Brain Res. 2004 Nov 4;130(1-2):187-90. doi: 10.1016/j.molbrainres.2004.07.006.
Our previous study revealed that the odor of hexanal, which is derived from the wood chips used as bedding, influenced mouse maternal behavior and induced the neonatal death of Fyn-deficient (fyn(-/-)) pups born of fyn(-/-) parents. To clarify what regions of the brain are involved in this effect, we examined which brain regions of fyn(-/-) and Fyn-heterozygous (fyn(+/-)) females were activated by hexanal odor using Fos immunohistochemistry. Hexanal induced Fos immunoreactivity in the primary olfactory cortex and in the medial and central amygdala of both fyn(+/-) and fyn(-/-) mice. In fyn(-/-) females, hexanal also induced the activation of the medial preoptic area and the basolateral and posteriomedial cortical amygdala, which are known to be involved in the control of maternal and emotional behavior.
我们之前的研究表明，作为垫料使用的木屑所产生的己醛气味会影响小鼠的母性行为，并导致fyn基因缺陷（fyn(-/-)）的亲代所生fyn(-/-)幼崽出现新生死亡。为了阐明大脑的哪些区域参与了这种效应，我们使用Fos免疫组织化学方法，检测了己醛气味可激活fyn(-/-)和Fyn杂合（fyn(+/-)）雌性小鼠的哪些脑区。己醛在fyn(+/-)和fyn(-/-)小鼠的初级嗅觉皮层以及内侧和中央杏仁核中诱导了Fos免疫反应性。在fyn(-/-)雌性小鼠中，己醛还诱导了内侧视前区以及基底外侧和后内侧皮质杏仁核的激活，这些脑区已知参与母性行为和情绪行为的控制。
