切除术后的肝脏再生：分子与细胞机制

[Liver regeneration after resection: molecular and cellular mechanism].

作者信息

Wakabayashi Go, Shimazu Motohide, Ueda Masakazu, Tanabe Minoru, Kawachi Shigeyuki, Kitajima Masaki

机构信息

Department of Surgery, Keio University School of Medicine, Tokyo, Japan.

出版信息

Nihon Geka Gakkai Zasshi. 2004 Oct;105(10):650-3.

PMID:15521380

Abstract

It has been well established that the liver can regenerate after resection. Liver regeneration is a fundamental mechanism by which the liver responds to injury. This review article discusses molecular and cellular mechanism of liver regeneration, including growth factors and cytokines in the initiation and regulation of liver regeneration, the importance of the liver extracellular matrix and its dynamic effect on hepatocyte growth, and finally, stem cell biology in liver regeneration.

摘要

肝脏切除后能够再生，这一点已经得到充分证实。肝再生是肝脏对损伤作出反应的一种基本机制。这篇综述文章讨论了肝再生的分子和细胞机制，包括生长因子和细胞因子在肝再生起始和调控中的作用、肝脏细胞外基质的重要性及其对肝细胞生长的动态影响，以及最后肝再生中的干细胞生物学。