Ciszowski Krzysztof, Modła Arkadiusz
Klinika Toksykologii Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie.
Przegl Lek. 2004;61(4):427-32.
The only venomous reptile that naturally occurs in Poland is the adder or common viper (Vipera berus). Its bites are not of great epidemiological importance, but in some cases serious life-threatening symptoms may appear. The most common symptoms of adder envenomation are: local edema, reddening and pain of the bitten site and also the general symptoms coming from the alimentary tract (vomiting, diarrhoea, abdominal pain), the circulatory system (hypotension, shock, ECG abnormalities), the central nervous system (sleepiness, vertigo, disorientation, loss of consciousness), hematological symptoms (leukocytosis, hemolysis, coagulopathy) and allergic symptoms (fever, urticaria, angio-oedema). In the present study we described the case of a twenty-year-old patient hospitalized at the Toxicology Department of the Collegium Medicum UJ after a viper bite. Except for some above-mentioned symptoms he also developed ocular symptoms like ptosis and blurred vision. Such symptoms after the common viper bite have not been described in the literature till now. The cause of them seems to be an intense allergic reaction in the region of the orbit and eyelids all the more so because the patient had the positive allergy history. However, taking into account the latest reports from the literature, a neurotoxic action of some components of the Vipera berus venom may also play a role. Because of the developing general symptoms a specific equine antivenom was administered to the patient, apart from the supportive care, without any serious side effects that usually are observed after the use of such a kind of sera. It is thought that the sheep antivenom is better than the equine one considering a lack of allergic side effects. As a result of applied treatment the local and general symptoms including ocular symptoms subsided.
波兰自然存在的唯一有毒爬行动物是蝰蛇或普通蝰蛇(草原蝰)。其咬伤在流行病学上并不十分重要,但在某些情况下可能会出现严重的危及生命的症状。蝰蛇咬伤最常见的症状有:咬伤部位局部水肿、发红和疼痛,以及来自消化道(呕吐、腹泻、腹痛)、循环系统(低血压、休克、心电图异常)、中枢神经系统(嗜睡、眩晕、定向障碍、意识丧失)、血液学症状(白细胞增多、溶血、凝血病)和过敏症状(发热、荨麻疹、血管性水肿)。在本研究中,我们描述了一名20岁患者被蝰蛇咬伤后在雅盖隆大学医学院毒理学系住院的病例。除了上述一些症状外,他还出现了眼睑下垂和视力模糊等眼部症状。普通蝰蛇咬伤后出现此类症状至今在文献中尚未有描述。其原因似乎是眼眶和眼睑区域发生了强烈的过敏反应,尤其是因为该患者有阳性过敏史。然而,考虑到文献中的最新报道,草原蝰毒液某些成分的神经毒性作用也可能起了作用。由于出现了全身症状,除了支持性治疗外,还给患者注射了特定的马抗蛇毒血清,且未出现使用此类血清后通常会观察到的任何严重副作用。考虑到没有过敏副作用,人们认为羊抗蛇毒血清比马抗蛇毒血清更好。经过治疗,局部和全身症状包括眼部症状都消退了。