Plouin-Gaudon I, Lengelé B, Desuter G, Rombaux P, Ledeghen S, Grégoire V, Hamoir M
Department of Head and Neck Surgery, Université Catholique de Louvain, St Luc University Hospital and Cancer Center, Brussels, Belgium.
Eur J Surg Oncol. 2004 Dec;30(10):1123-30. doi: 10.1016/j.ejso.2004.08.011.
This study reports the treatment of a cohort of patients with pyriform sinus squamous cell carcinoma, using conservative surgery and radiotherapy.
Thirty-four patients with pyriform sinus SCC were treated between 1986 and 2001, using partial laryngopharyngectomy with or without complementary radiotherapy. Seventy-six percent had stage III-IV lesions. Quality of life questionnaire and clinical examination were used for evaluation of laryngeal function.
Conservation surgery was undertaken. All patients underwent neck dissection. Two thirds of the patients received post-operative radiotherapy. Reconstruction was achieved by local muscular flap in 13 cases, radial forearm free flap in 18 and pectoralis major flap in three. Five-year overall and disease-specific survival rates were 50 and 65%, respectively. Successful laryngeal function preservation with local control was achieved in 80% of the patients.
Partial laryngopharyngectomy is a suitable treatment for early and selected advanced stage pyriform sinus carcinoma with a good functional and oncologic outcome.
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