紫外线辐射暴露与基底细胞癌部位及组织学之间的关联。

Associations between UVR exposure and basal cell carcinoma site and histology.

作者信息

Lovatt Tracy J, Lear John T, Bastrilles Jean, Wong Christina, Griffiths Christopher E M, Ramachandran Sudarshan, Smith Andrew G, Salim Asad, Fryer Anthony A, Jones Peter W, Strange Richard C

机构信息

Institute of Science and Technology in Medicine, Keele University School of Medicine, Hartshill Campus, University Hospital of North Staffordshire, Staffordshire, UK.

出版信息

Cancer Lett. 2004 Dec 28;216(2):191-7. doi: 10.1016/j.canlet.2004.08.008.

DOI:10.1016/j.canlet.2004.08.008

PMID:15533595

Abstract

While sunlight is critical in basal cell carcinoma (BCC) pathogenesis the relationship between exposure and tumor site and histology is unclear. We determined if tumor site (trunk or head/neck) or histology (nodular or superficial) is determined by exposure pattern. In 66 cases with truncal and 362 patients with head/neck BCC at first presentation, average hours exposure/year, intermittency score, childhood sunburning and skin type were not significantly associated with tumor site or histology. However, often sunbathing was associated with a five-fold increased risk of truncal BCC. Average sunbathing score was significantly greater in 22 cases with truncal compared with 325 cases with head/neck nodular tumors and also in 44 cases with superficial truncal compared with superficial head/neck BCC. Thus, sunbathing determined tumor site but not histology.

摘要

虽然阳光在基底细胞癌（BCC）发病机制中至关重要，但暴露与肿瘤部位及组织学之间的关系尚不清楚。我们确定肿瘤部位（躯干或头颈部）或组织学（结节状或浅表性）是否由暴露模式决定。在66例初诊时患有躯干BCC的患者和362例患有头颈部BCC的患者中，每年平均暴露小时数、间歇性评分、儿童期晒伤和皮肤类型与肿瘤部位或组织学均无显著关联。然而，经常日光浴与躯干BCC风险增加五倍相关。与325例头颈部结节状肿瘤患者相比，22例躯干BCC患者的平均日光浴评分显著更高；与浅表性头颈部BCC患者相比，44例浅表性躯干BCC患者的平均日光浴评分也显著更高。因此，日光浴决定肿瘤部位而非组织学。