Lovatt Tracy J, Lear John T, Bastrilles Jean, Wong Christina, Griffiths Christopher E M, Ramachandran Sudarshan, Smith Andrew G, Salim Asad, Fryer Anthony A, Jones Peter W, Strange Richard C
Institute of Science and Technology in Medicine, Keele University School of Medicine, Hartshill Campus, University Hospital of North Staffordshire, Staffordshire, UK.
Cancer Lett. 2004 Dec 28;216(2):191-7. doi: 10.1016/j.canlet.2004.08.008.
While sunlight is critical in basal cell carcinoma (BCC) pathogenesis the relationship between exposure and tumor site and histology is unclear. We determined if tumor site (trunk or head/neck) or histology (nodular or superficial) is determined by exposure pattern. In 66 cases with truncal and 362 patients with head/neck BCC at first presentation, average hours exposure/year, intermittency score, childhood sunburning and skin type were not significantly associated with tumor site or histology. However, often sunbathing was associated with a five-fold increased risk of truncal BCC. Average sunbathing score was significantly greater in 22 cases with truncal compared with 325 cases with head/neck nodular tumors and also in 44 cases with superficial truncal compared with superficial head/neck BCC. Thus, sunbathing determined tumor site but not histology.
虽然阳光在基底细胞癌（BCC）发病机制中至关重要，但暴露与肿瘤部位及组织学之间的关系尚不清楚。我们确定肿瘤部位（躯干或头颈部）或组织学（结节状或浅表性）是否由暴露模式决定。在66例初诊时患有躯干BCC的患者和362例患有头颈部BCC的患者中，每年平均暴露小时数、间歇性评分、儿童期晒伤和皮肤类型与肿瘤部位或组织学均无显著关联。然而，经常日光浴与躯干BCC风险增加五倍相关。与325例头颈部结节状肿瘤患者相比，22例躯干BCC患者的平均日光浴评分显著更高；与浅表性头颈部BCC患者相比，44例浅表性躯干BCC患者的平均日光浴评分也显著更高。因此，日光浴决定肿瘤部位而非组织学。
