痴呆症中的血管因素：概述

Vascular factors in dementia: an overview.

作者信息

Decarli Charles

机构信息

Department of Neurology, University of California at Davis, 4860 Y St. Suite 3700, Sacramento CA 95817, USA.

出版信息

J Neurol Sci. 2004 Nov 15;226(1-2):19-23. doi: 10.1016/j.jns.2004.09.005.

DOI:10.1016/j.jns.2004.09.005

PMID:15537513

Abstract

Alzheimer's disease and cerebrovascular disease are two illnesses common to the elderly. Conventional wisdom has sought to separately describe and treat these two diseases. Accumulating evidence, however, shows that cerebrovascular risk factors may cause asymptomatic brain injury, share genetic risk with Alzheimer's disease and possibly accelerate the Alzheimer's process. Such evidence suggests that these two diseases may act additively or synergistically to cause clinical dementia. This review focuses on evolving data that support this hypothesis.

摘要

阿尔茨海默病和脑血管疾病是老年人常见的两种疾病。传统观念一直试图分别描述和治疗这两种疾病。然而，越来越多的证据表明，脑血管危险因素可能导致无症状性脑损伤，与阿尔茨海默病存在共同的遗传风险，并可能加速阿尔茨海默病的进程。这些证据表明，这两种疾病可能以相加或协同的方式导致临床痴呆。本综述重点关注支持这一假说的不断发展的数据。