组蛋白去乙酰化酶4：一种控制骨骼发育的共抑制因子。
HDAC4: a corepressor controlling bone development.
作者信息
Hug Bruce A
机构信息
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Cell. 2004 Nov 12;119(4):448-9. doi: 10.1016/j.cell.2004.10.023.
PMID:15537533
Abstract
RUNX2 is a transcription factor with a well-characterized role in bone development. In this issue of Cell, Vega and colleagues (Vega et al., 2004) show that HDAC4 interacts with RUNX2 and impacts upon chondrocyte hypertrophy and bone formation.
摘要
RUNX2是一种在骨骼发育中具有明确作用的转录因子。在本期《细胞》杂志中，维加及其同事（维加等人，2004年）表明，HDAC4与RUNX2相互作用，并影响软骨细胞肥大和骨形成。
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