醛固酮受体阻滞剂在高血压治疗中的应用。
The use of aldosterone receptor blockers in the treatment of hypertension.
作者信息
Weinberger Myron H
机构信息
Indiana University School of Medicine, 541 Clinical Drive, Room 423, Indianapolis, IN 46202, USA.
出版信息
J Clin Hypertens (Greenwich). 2004 Nov;6(11):632-5. doi: 10.1111/j.1524-6175.2004.03057.x.
The emerging role of aldosterone in hypertension and cardiovascular diseases has prompted a renewal of interest in therapeutic approaches designed to interfere with the action of this mineralocorticoid hormone. While spironolactone has long been used for this purpose, side effects, largely attributable to the interaction of this agent with non-mineralocorticoid steroid receptors, has reduced the enthusiasm for its use. Eplerenone, a specific aldosterone receptor blocker with a lower incidence of the sex hormone-related side effects than spironolactone, has been used in several recent clinical trials in hypertension and congestive heart failure. This review will highlight the major findings from these studies.
醛固酮在高血压和心血管疾病中日益凸显的作用，促使人们重新关注旨在干扰这种盐皮质激素作用的治疗方法。虽然螺内酯长期以来一直用于此目的，但主要归因于该药物与非盐皮质激素类固醇受体相互作用的副作用，降低了人们对其使用的热情。依普利酮是一种特异性醛固酮受体阻滞剂，与性激素相关的副作用发生率低于螺内酯，已在最近几项高血压和充血性心力衰竭的临床试验中使用。本综述将重点介绍这些研究的主要发现。
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