成人T细胞白血病/淋巴瘤中腺瘤性息肉病 coli（APC）基因的甲基化分析
Methylation analysis of the adenomatous polyposis coli (APC) gene in adult T-cell leukemia/lymphoma.
作者信息
Yang Yang, Takeuchi Seisho, Tsukasaki Kunihiro, Yamada Yasuaki, Hata Tomoko, Mori Naoki, Fukushima Atsuki, Seo Hiromi, Koeffler H Phillip, Taguchi Hirokuni
机构信息
Department of Medicine, Kochi Medical School, Okohcho, Nankoku, Kochi 783-8505, Japan.
出版信息
Leuk Res. 2005 Jan;29(1):47-51. doi: 10.1016/j.leukres.2004.05.004.
We investigated methylation status of the adenomatous polyposis coli (APC) gene in adult T-cell leukemia/lymphoma (ATL). APC methylation was found in 15 of 31 (48%) primary samples, and 2 of 4 (50%) ATL cell lines. Methylation of the APC gene occurred more frequently in acute ATL (12/21) (57%) than chronic ATL (1/8) (13%) (P = 0.03). APC was not expressed in the APC-methylated ATL cell line ST1. Demethylation with 5-azacytidine treatment restored APC expression in the ST1 cell line. Our data show that hypermethylation of the APC gene is involved in the pathogenesis of ATL.
我们研究了成人T细胞白血病/淋巴瘤（ATL）中腺瘤性息肉病 coli（APC）基因的甲基化状态。在31份原发性样本中的15份（48%）以及4份ATL细胞系中的2份（50%）发现了APC甲基化。APC基因的甲基化在急性ATL（12/21）（57%）中比慢性ATL（1/8）（13%）更频繁发生（P = 0.03）。在APC甲基化的ATL细胞系ST1中未检测到APC表达。用5-氮杂胞苷处理进行去甲基化可恢复ST1细胞系中的APC表达。我们的数据表明，APC基因的高甲基化参与了ATL的发病机制。
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