Cena Clara, Boschi Donatella, Tron Gian Cesare, Chegaev Kostantin, Lazzarato Loretta, Di Stilo Antonella, Aragno Manuela, Fruttero Roberta, Gasco Alberto
Dipartimento di Scienza e Tecnologia del Farmaco, Via P. Giuria 9, I-10125 Torino, Italy.
Bioorg Med Chem Lett. 2004 Dec 20;14(24):5971-4. doi: 10.1016/j.bmcl.2004.10.006.
A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine.
描述了一类新型的一氧化氮供体酚衍生物。这些产物是通过将合适的酚与硝基氧基或3-苯基磺酰基呋咱-4-基氧基部分连接而获得的。所有化合物均被证明可抑制亚铁盐/抗坏血酸诱导的大鼠肝细胞膜脂质的脂质过氧化。它们还能够舒张用去氧肾上腺素预收缩的大鼠主动脉条。
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