Altenhoff Gereon, Goddard Richard, Lehmann Christian W, Glorius Frank
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.
J Am Chem Soc. 2004 Nov 24;126(46):15195-201. doi: 10.1021/ja045349r.
A unique family of N-heterocyclic carbenes derived from bioxazolines (IBiox) suitable for application in transition-metal catalysis is described. The ligands are electron rich, sterically demanding, and have restricted flexibility. Their usefulness has been demonstrated in the Suzuki-Miyaura cross-coupling of sterically hindered aryl chlorides and boronic acids. For the first time, tetraortho-substituted biaryls with methyl and larger ortho-substituents have been synthesized from aryl chlorides using the Suzuki-Miyaura method.
本文描述了一类独特的源自生物恶唑啉（IBiox）的N-杂环卡宾，适用于过渡金属催化。这些配体电子丰富、空间位阻大且具有受限的灵活性。它们在空间位阻较大的芳基氯与硼酸的铃木-宫浦交叉偶联反应中的实用性已得到证明。首次使用铃木-宫浦方法从芳基氯合成了具有甲基和更大邻位取代基的四邻位取代联芳基。
