钌催化的双环烯烃与卤代炔烃之间的[2 + 2]环加成反应。
Ruthenium-catalyzed [2 + 2] cycloadditions between bicyclic alkenes and alkynyl halides.
作者信息
Villeneuve Karine, Riddell Nicole, Jordan Robert W, Tsui Gavin C, Tam William
机构信息
Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry, Department of Chemistry, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
出版信息
Org Lett. 2004 Nov 25;6(24):4543-6. doi: 10.1021/ol048111g.
Ru-catalyzed [2 + 2] cycloadditions between norbornadiene and alkynyl halides were found to occur in moderate to good yields (32-89%). The presence of the halide moiety greatly enhances the reactivity of the alkyne component in the cycloaddition and can be transformed into a variety of products that are difficult or impossible to obtain via direct cycloaddition. [reaction: see text]
人们发现，钌催化的降冰片二烯与卤代炔之间的[2 + 2]环加成反应能以中等至良好的产率（32 - 89%）发生。卤化物部分的存在极大地提高了环加成反应中炔烃组分的反应活性，并且可以转化为多种通过直接环加成难以或无法获得的产物。[反应：见正文]
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