Strnad Vratislav
Department of Radiation Oncology, University of Erlangen, Erlangen, Germany.
Strahlenther Onkol. 2004 Nov;180(11):710-7. doi: 10.1007/s00066-004-9196-x.
Excellent local control rates of interstitial brachytherapy in oral cavity cancer and oropharyngeal carcinoma have been demonstrated in different retrospective studies. Compared to external-beam radiation therapy the high local control rates with a low rate of side effects obtained by interstitial brachytherapy are the result of a steep dose reduction in the implant-surrounding normal tissues. Therefore, interstitial brachytherapy offers rather the possibility to give high doses without inevitably leading to high complication rates. Low-dose-rate (LDR) and pulsed-dose-rate (PDR) interstitial brachytherapy with 0.4-0.55 Gy/h/24 h for tumors of the oral cavity and oropharynx in selected patients is a proven, effective and safe treatment method with excellent long-term data both as a sole treatment modality and a postoperative method, as well as a unique treatment method of head and neck tumors in previously irradiated areas. This paper deals with the technical aspects of interstitial brachytherapy, that seem to be relevant to high-quality outcome, and gives an overview of indications as well as past and recent results of interstitial brachytherapy in head and neck cancer.
不同的回顾性研究已证实，口腔癌和口咽癌采用间质近距离放射治疗具有出色的局部控制率。与外照射放疗相比，间质近距离放射治疗能获得高局部控制率且副作用发生率低，这是因为植入周围正常组织的剂量急剧降低。因此，间质近距离放射治疗提供了给予高剂量而不一定导致高并发症发生率的可能性。对于选定患者的口腔和口咽肿瘤，采用低剂量率（LDR）和脉冲剂量率（PDR）间质近距离放射治疗，剂量为0.4 - 0.55 Gy/h/24 h，作为一种单一治疗方式、术后治疗方法以及先前照射区域头颈肿瘤的独特治疗方法，是一种经过验证的、有效且安全的治疗方法，有出色的长期数据支持。本文论述了间质近距离放射治疗的技术方面，这些方面似乎与高质量治疗结果相关，并概述了间质近距离放射治疗在头颈癌中的适应症以及过去和近期的治疗结果。
